目的 观察沙丁胺醇联合异丙托溴铵在改善早产儿呼吸系统疾病的疗效, 为临床诊治提供参考依据。方法 将112例早产肺类或呼吸窘迫征患儿随机分为治疗组、对照组, 治疗组在常规治疗的基础上, 入院后给予沙丁胺醇和异丙托溴铵雾化吸入, 对照组仅给予常规治疗。结果 治疗组发生呼吸困难、低氧血症、外周给氧、呼吸暂停、单纯血氧饱和度下滑情况与对照组相比, 差异均无统计学意义(P>0.05);治疗组呼吸困难缓解时间、低氧血症纠正时间、外周给氧时间、呼吸暂停缓解时间、单纯血氧饱和度下滑缓解时间与对照组相比, 差异均有统计学意义(P<0.05), 且治疗组症状和体征缓解时间均短于对照组。结论 沙丁胺醇联合异丙托溴铵雾化吸入治疗早产儿呼吸系统疾病, 不能减少其呼吸困难、低氧血症、呼吸暂停等症状和体征的发生, 不能避免外周给氧, 但能改善症状, 缩短给氧时间, 缩短病程。

Objective To observate the effects of salbutamol and ipratropium for preterm children of oxygenation. Methods A total of 112 cases of premature children were randomly divided into treatment group and control group, treatment group were given salbutamol and ipratropium bromide inhalation after admission on the basis of conventional therapy;Control group received conventional therapy only. Results Treatment group had dyspnea, hypoxemia, peripheral oxygen, apnea, only oxygen fell, the difference was not statistically significant compared with control group(P>0.05);dyspnea relief time, time to correct hypoxemia, peripheral oxygen time, apnea relief time, pure oxygen saturation fell remission time, which occurred in the treatment group compared with the control group, the differences were statistically significant(P<0.05).The signs and symptoms remission of treatment group were shorter than those of the control group. Conclusions Salbutamol and ipratropium bromide treatment of respiratory disease in preterm children, could not reduce their dyspnea, hypoxemia, apnea and other signs and symptoms.Peripheral oxygen can not be avoided, but it can improve symptoms and shorten the oxygen time, and also shorten the course.