抽动障碍动物模型研究进展
- 车立纯1 综述, 衣明纪1,刘秀梅2 审校
作者信息
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文章历史
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摘要
近年来抽动障碍(tic disorder,TD)患病率逐渐升高。TD的病因及治疗学研究离不开动物模型。常用的TD动物模型包括多巴胺、5-羟色胺、兴奋性氨基酸、一氧化氮失调模型以及自身免疫模型、分离综合征模型、转基因模型等。这些动物模型通常只能部分地模拟TD患者的临床行为学和神经生化改变。目前国内TD模型以亚氨基二丙腈(IDPN)、2,5-二甲氧-4-碘苯-2-氨基丙烷(DOI)等化学因素诱发的动物模型为主,主要研究TD防治药物的作用机制;国外TD模型以自身免疫模型、基因工程模型为主,主要探究TD的发病机制。
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参考文献
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[2] Huys D,Hardenacke K,Poppe P,et al.Update on the role of antipsychotics in the treatment of Tourette syndrome[J].Neuropsychiatric Disease and Treatment,2012,8(5):95-104.
[3] Steed E,Jones CA,McCreary AC.Serotonergic involvement in methamphetamine-induced locomotor activity:a detailed pharmacological study[J].Behav Brain Res,2011,220(1):9-19.
[4] 卫利,王素梅,崔霞,等.多发性抽动症动物模型的比较与评价[J].中华行为医学与脑科学杂志,2012,21(2):187-189.
[5] Lv H,Li A,Liu F,et al.Effects of gastrodin on the dopamine system of Tourette's syndrome rat models[J].Biosci Trends,2009,3(2):58-62.
[6] Bronfeld M,Israelashvili M,Bar-Gad I.Pharmacological animal models of Tourette syndrome[J].Neurosci Biobehav Rev,2012,7634 (12):163-7.
[7] Al Kadasah S,Al Mutairy A,Siddiquei M,et al.Pentoxifylline attenuates iminodipropionitrile-induced behavioral abnomalities in rats[J].Behav Pharmacol,2009,20(4):356-360.
[8] 张如意,艾厚喜,张丽.拟抽动秽语综合症大鼠模型的复制及再评价[J].中国精神神经病杂志,2010,36(6):552-554.
[9] Li JJ,Li ZW,Li AY,et al.Abnormal expression of dopamine and serotonin transporters associated with the pathophysiologic mechanism of Tourette syndrome[J].Neurol India,2010,58(4):523-529.
[10] 姚阳,刘坤.DOI诱导的Wistar大鼠头部抽动模型脑内VMAT2的表达[J].解剖科学进展,2011,17(1):48-50.
[11] Mueller PJ,Mischel NA.Selective enhancement of glutamate-mediated pressor responses after GABA(A) receptor blockade in the RVLM of sedentary versus spontaneous wheel running rats[J].Front Physiol,2012,3(12):447-455.
[12] Nazari QA,Mizuno K,Kume T.In vivo brain oxidative stress model induced by microinjection of sodium nitroprusside in mice[J].Pharmacol Sci,2012,120(2):105-111.
[13] Yaddanapudi K,Hornig M,Serge R,et al.Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection[J].Mol Psychiatry,2010,15(7):712-726.
[14] Loiselle CR,Lee O,Moran TH,et al.Striatal microinfusion of Tourette syndrome and PANDAS sera:failure to induce behavioral changes[J].Mov Disord,2004,19(4):390-396.
[15] Hoffman KL,Hornig M,Yaddanapudi K,et al.A murine model for neuropsychiatric disorders associated with group A beta-hemolytic streptococcal infection[J].J Neurosci,2004,24(7):1780-1791.
[16] Lovic V,Keen D,Fletcher PJ,et al.Early-life maternal separation and social isolation produce an increase in impulsive action but not impulsive choice[J].Behav Neurosci,2011,125(4):481-491.
[17] Meng Q,Li N,Han X,et al.Peri-adolescence isolation rearing alters social behavior and nociception in rats[J].Neurosci Lett,2010,480(1):25-29.
[18] Marsden CA,King MV,Fone KC.Influence of social isolation in the rat on serotonergic function and memory--relevance to models of schizophrenia and the role of 5-HT6 receptors[J].Neuropharmacology,2011,61(3):400-407.
[19] Cain ME,Mersmann MG,Gill MJ,et al.Dose-dependent effects of differential rearing on amphetamine-induced hyperactivity[J].Behav Pharmacol,2012,23(8):744-753.
[20] Cáceda R,Binder EB,Kinkead B,et al.The role of endogenous neurotensin in psychostimulant-induced disruption of prepulse inhibition and locomotion[J].Schizophr Res,2012,136(1-3):88-95.
[21] Swerdlow NR,Bongiovanni MJ,Tochen L,et al.Separable no radrenergic and dopaminergie regulation of prepulse inhibition in rats:implications for predicttive validity and Tourette syndrome[J].Psychopharmacology,2006,186(2):246-254.
[22] Nordstrom EJ,Burton FH.A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry[J].Mol Psychiatry,2002,7(6):617-625.
基金
国家自然科学基金资助项目(81101017);山东省优秀中青年科学家科研奖励基金(BS2010F030);烟台市科学技术发展计划项目(2010148-24)
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