目的 观察学龄期肥胖与体重正常儿童血清25羟维生素D[25(OH)D]水平及其与儿童肥胖程度及糖脂代谢的关系。方法 按照《中国0~18岁儿童青少年体块指数的生长曲线》标准,从学龄期儿童中筛选出超重和肥胖儿童作为肥胖组,并设置同年龄、体重正常儿童为对照组。采用ELSIA测定血清25羟维生素D[25(OH)D]、甲状旁腺素(parathyroid hormone,PTH),全自动生化分析仪测定血生化指标。结果 肥胖儿童59人(男童45人,女童14人),平均年龄(9.58±2.39)岁,BMI 为25.14±4.02;对照组35人(男童23人,女童12人),平均年龄(8.92±1.56)岁,BMI为15.56±1.51。肥胖组儿童血清25(OH)D(45.40±11.86)nmol/L明显低于对照组儿童(59.56±16.08)nmol/L,差异有高度统计学意义(P<0.001),骨密度低于正常组儿童(P<0.001);血清25(OH)D浓度与BMI SDS、腰围、腰臀比及血甘油三脂呈显著负相关(P<0.05);25(OH)D低于50 nmol的肥胖儿童的甘油三脂水平[(2.08±0.26) mmol/L]明显高于25(OH)D大于50 nmol的肥胖儿童[(1.41±0.14) mmol/L]。 结论 肥胖儿童血清25(OH)D浓度明显低于体重正常儿童,血清25(OH)D浓度与儿童BMI SDS、腰围、甘油三脂呈负相关提示维生素D缺乏可能是儿童中心性肥胖和代谢综合症的危险因素。
Abstract
Objective To compare the serum 25(OH)D concentrations between obesity children and normal weight children,and to investigate the relationships between 25(OH)D and childhood obesity,glucose and lipid metabolism. Methods Obesity was defined according to "Body mass index growth curves for Chinese children and adolescents aged 0~18 years".The serum 25(OH)D concentrations and parathyroid hormone (PTH) were determined by enzyme linked immunosorbent assay (ELISA).Biochemistry index were assayed by automatic chemistry analysis. Results There were 59 obese children (male 45,female 14,BMI 25.14±4.02) with average age (9.58±2.39) years old,and 35 normal weight children (male 23,female 12,BMI 15.56±1.51) aged (8.92±1.56) years old as control recruited in this study.The serum 25(OH)D concentrations [(45.40±11.86)nmol/L] in obese children were lower compared to control group (59.56±16.08)nmol/L(P<0.001).The serum 25(OH)D concentration was inversely related with BMI SDS (P<0.001),waist circumference (P<0.001),waist-to-hip ratio (r=-0.393,P=0.001) and blood triglyceride (P=0.036).Moreover,triglyceride level in obese children with vitamin D deficiency [serum 25(OH)D ≤50 nmol /L] was higher than that in obese children with 25(OH)D > 50 nmol /L. Conclusions The serum 25(OH) D levels in obese children are lower than those in normal weight children;the serum 25(OH) D is negatively correlated with BMI SDS,waist circumference and blood triglyceride,which implying that vitamin D deficiency may be a risk factor of visceral obesity and metabolism syndrome.
关键词
肥胖 /
维生素D /
儿童
Key words
obesity /
vitamin D /
children
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基金
国家自然科学基金(81273064);南京医学科技发展基金(YKK10051)
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