关键词: Kiss肽, G蛋白偶联受体54, 性早熟, 青春期, 女童

Abstract: Objective To explore the role of Kisspeptins in the onset of idiopathic central precocious puberty and realize the significance about diagnosis and treatment by detecting the level of Kisspeptins in blood serum. Methods A total of 40 girls aged 6~8 years old were divided into 2 groups by assessment of growth and development and correlated examinations:20 healthy girls of TannerⅠin control group,20 ICCP girls of Tanner II in study group,ICCP girls were treated with GnRHa for six month.And then the levels of luteinizing hormone by Chemiluminescence and Kisspeptins were detected by Western Blot. Results Compared with the control group,the level of Kisspeptins in study group before treatment increased 0.86 fold (P<0.01); compared with the study group before treatment,the level of Kisspeptins in study group after treatment decreased 0.97 fold (P<0.01);the level of Kisspeptins in study group before treatment was positive correlated with both the peak value of LH and their bone ages individually,the Spearman correlation coefficients were 0.42 and 0.38(P<0.05);the level of Kisspeptins in study group after treatment was not correlated with both the peak value of LH and their bone ages individually,the Spearman correlation coefficients were 0.05 and 0.09(P>0.05). Conclusion Kisspeptins/GPR54 system may play an important role in the onset of idiopathic central precocious puberty,the level of Kisspeptins in blood serum has a guiding significance for diagnosing and treating idiopathic central precocious puberty.

Key words: Kisspeptins, G protein-coupled receptor 54 , precocious puberty, puberty, girls