【目的】 探讨早产儿血清胃泌素(gastrin,GAS)水平与喂养量的相关性。【方法】 将42例早产儿分为观察组(有喂养不耐受)22例与对照组(无喂养不耐受)20例。两组患儿分别在生后24 h内及7日龄后行血清胃泌素水平的测定,观察两组患儿治疗一周后临床状况改善情况。【结果】 观察组在入院时的血清胃泌素水平及当日每公斤体重奶量较对照组显著减低,治疗7 d后两组血清胃泌素水平差异无统计学意义;观察组在达全量肠内营养时间、恢复至出生体重时间较对照组显著延长(P<0.05或<0.01),而在住院期间血清总胆红素水平高峰值及血清前白蛋白水平方面差异无统计学意义(P>0.05)。两组患儿均未发生一例坏死性小肠结肠炎,吸入性肺炎等严重的喂养并发症。两组患儿血清胃泌素水平与检测当日每公斤体重奶量的相关性分析呈正相关(r=0.589,P<0.01)。【结论】 早产儿血清GAS水平与胃肠功能紊乱的发生关系密切,微量喂养可促进早产儿胃肠道发育成熟。

【Objective】 To explore dependablity between the levels of serum gastrin and feeding quantity in premature infants. 【Methods】 42 cases of the premature infants were divided into the two groups:the observe group,which 22 cases of neonatus with feeding intolerance,and the controled group,which 20 cases of neonatus without feeding intolerance.Two groups were detected serum gastrin in 24 h and after 7 days respectively and were observed in clinical condition improved treatment after a week. 【Results】 The levels of the serum GAS and the amount of feeding(Per kilogram of body weight)in premature infants with feeding intolerance were significently lower in 24 h than those in the control group(P<0.05),then they were not significantly different between the two groups after 7 days(P>0.05).The time to establish complete enteral nutrition,days to regain birth weight were significently longer in the observe group than those in the control group,however,the horizontal peak value of total bilirubin of serum and the levels of serum prealbumin were no significant difference between the two groups.None of the two groups have the severe complications such as the necrotized enterocolitis and the inhaled pneumonia.In group 2,there was a positive correlation between the levels of the serum GAS and the amount of feeding(Per kilogram of body weight)(r=0.589,P<0.01). 【Conclusions】 The levels of serum GAS is in close relation with emergence of the function disorder of gastrointestinal tract.The Minimal feeding can promote gastrointestinal developing ripeness.