FOXE1基因突变与甲状腺发育不全

李玉芬,张立琴

中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (2) : 149-150.

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PDF(298 KB)
中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (2) : 149-150.
综述与讲座

FOXE1基因突变与甲状腺发育不全

  • 李玉芬,张立琴
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摘要

甲状腺发育不全(thyroid dysgenesis,TD)是先天性甲状腺功能低下症(thyroid hypofunction,CH)的病因之一,约2%~3%的TD与甲状腺发育过程中的转录因子突变有关系,FOXE1突变是当前研究的热点,本文就FOXE1的结构、基因突变位点、突变的功能及与甲状腺发育的关系进行了综述,为其基因研究提供依据。

关键词

甲状腺发育不全 / FOXEI基因 / 儿童

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导出引用
李玉芬,张立琴. FOXE1基因突变与甲状腺发育不全[J]. 中国儿童保健杂志. 2012, 20(2): 149-150
中图分类号: R725.8   

参考文献

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基金

青岛市科技局科技发展项目(10-3-3-2-3-nsh)

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