【目的】 了解南宁市超重、肥胖儿童非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)的检出情况。【方法】 对本院小儿内分泌科门诊就诊的180例超重、肥胖患儿进行身高、体重、腰围等测量,同时进行肝肾功能、血糖、胰岛素、肝脏B超等相关检测。【结果】 180例患儿中B超明确脂肪肝66例(男42例,女24例),非脂肪肝114例(男64例,女50例),NAFLD检出率为36.7%(66/180),其中男童检出率为39.6%(42/106),女童检出率为32.4%(24/74),男女差异无统计学意义(χ2=0.394,P=0.319);脂肪肝组体质指数、腰围、血压、血脂等指标均高于非脂肪肝组。【结论】 南宁市超重、肥胖儿童的NAFLD的发生率为36.7%,控制儿童超重、肥胖的发生,是防治儿童青少年NAFLD的重要措施;谷丙转氨酶能否用于超重、肥胖儿童NAFLD早期识别的依据值得探讨。
Abstract
【Objective】 To find out the incidence of nonalcoholic fatty liver disease in overweight and obesity children in Nanning,Guangxi. 【Methods】 180 children in endocrine apartment of our hospital were examined. 【Result】 The incidence of overweight and obesity children(Male)were 13.5%,8.4%;and the incidence of overweight and obesity children(Female)were 7.9%,6.6%;66 children in 180 were diagnosed nonalcoholic fatty liver disease;the prevalence was 36.7%,the incidence of male was 39.6%,and the incidence of female was 32.4%,which had no significant statistic means between male and female.The indexes of NAFLD children were much higher than non-NAFLD children,ALT and HOMA-IR were independent risk factors of NAFLD. 【Conclusion】 The incidence of nonalcoholic fatty liver disease in overweight and obesity children in Nanning is 36.7%,ALT and HOMA-IR are independent risk factors of NAFLD.
关键词
超重 /
肥胖 /
非酒精性脂肪肝 /
检出率 /
儿童
Key words
overweight /
obesity /
nonalcoholic fatty liver disease /
incidence /
children
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基金
十一五国家科技支撑计划项目 (2009BAI80B00);广西自然科学基金项目(0832184)
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