谷氨酸及其受体在缺氧缺血性脑损伤中的作用

王平,吕士申,安丽,任翠云

中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (1) : 52-54.

PDF(454 KB)
PDF(454 KB)
中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (1) : 52-54.
综述与讲座

谷氨酸及其受体在缺氧缺血性脑损伤中的作用

  • 王平1,吕士申2,安丽2,任翠云3
作者信息 +
文章历史 +

摘要

新生儿缺氧缺血性脑损伤可导致围生期新生儿死亡或神经系统的发育障碍等严重后遗症。研究发现,缺氧缺血导致脑组织中谷氨酸在神经元周围过度蓄积,并作用于不同类型的受体,造成不同部位的神经元兴奋性中毒乃至死亡。谷氨酸拮抗剂减轻谷氨酸释放和钙超载,谷氨酸受体拮抗剂能有效阻断兴奋毒性,减轻脑组织损伤,从而为新生儿脑损伤的防治提供了新的思路。

关键词

缺氧缺血性脑病 / 谷氨酸 / 受体 / 新生儿

引用本文

导出引用
王平,吕士申,安丽,任翠云. 谷氨酸及其受体在缺氧缺血性脑损伤中的作用[J]. 中国儿童保健杂志. 2012, 20(1): 52-54
中图分类号: R722.12   

参考文献

[1] Kimberly A,Allen,Debra H.Brandon.Hypoxic ischemic encephalopathy:pathophysiology and experimental treatments[J].Newborn and Infant Nursing Reviews,2011,3:125-133.
[2] 卢红艳,吴丽华.缺氧缺血性脑病治疗时间窗的研究进展[J].中国新生儿科杂志,2010,25(5):313-315.
[3] Fukuda S,Mizuno K,Kawai S.Reduction in cerebral blood flow volume in infants complicatedwith hypoxic ischemic encephalopathy resulting in cerebral palsy[J].Brain & Development,2008,30:246-253.
[4] Hany A,Mohamed T.Mostafa K,et al.IL-1β,IL-6 and TNF-α and outcomes of neonatal hypoxic ischemic encephalopathy[J].Brain & Development,2006,28:178-182.
[5] 潘燕,张保朝,张小林.脑缺血后神经调剂素-1对缺血边缘区细胞凋亡的影响及机制[J].中国实用神经疾病杂志,2011,4(14):24-26.
[6] 黄晓磊,王树礼.谷氨酸、NMDA受体1与缺血性脑损伤关系研究进展[J].中国微循环, 2006,10(1): 69-72.
[7] Ga'bor Sze'na'si,Vegh M,Szabo G,et al.2,3-Benzodiazepine-type AMPA receptor antagonists and their neuroprotective effects[J].Neurochemistry International,2008,52:166-183.
[8] Burke DM,Raymond CK,Lee JM.Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia[J].J Devl Neuroscience,2008,26:67-76.
[9] Feng Z,Philip GR,Abhay JB.Hypoxic preconditioning provides neuroprotection and increases vascular endothelial growth factor A,preserves the phosphorylation of Akt-Ser-473 and diminishes the increase in caspase-3 activity in neonatal rat hypoxic-ischemic model[J].Brain Research,2010,1325:1-9.
[10] 刘志安,赵娓娓,吕春娥,等.NMDAR亚单位1在AD样大鼠海马的表达及其与细胞凋亡的关系[J].中国老年学杂志,2011,31(2):273-276.
[11] Micu I,Jiang Q,Coderre E,et al.NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia[J].Nature,2006,439:988-992.
[12] Chidambaram SB,Muthiah R.Post-ischemic administration of nimodipine following focal cerebral ischemic-reperfusion injury in rats alleviated excitotoxicity, neurobehavioural alterations and partially the bioenergetics[J].Int J Devl Neuroscience,2010,8:1-13.
[13] Marc A,Michael J.Ultrastructural relationship between the AMPA-GluR2 receptor subunit and the mu-opioid receptor in the mouse central nucleus of the amygdala[J].Experimental Neurology,2011,22:149-158.
[14] Ailzai T,Tsuzuki K,Yamada N,et al.Over-expression of Ca2+ permeable AM A receptor promotes delayed cell death of hippocam pal CA1 neurons followingtransient forebrain ischemia[J].Neurosci Res,2003,46:41-51.
[15] Szenasi G,Vegh M,Szabo G,et al.2,3-benzodiazepine-type AMPA receptor antagonists and their neuroprotective effects[J].J Neurochemistry,2005,52:166-183.
[16] 陈丽,刘健,桂振华.代谢型谷氨酸受体5拮抗剂对临床早期帕金森病模型大鼠行为变化的影响及神经保护作用[J].四川大学学报:医学版,2011,42 (1):65-68.
[17] 侯亚利,张玉平.益母草注射液减少DIC大鼠多个组织器官一氧化氮合成与释放的实验研究 [J].时珍国医国药,2010,21(12):3135-3136.
[18] 杨峰霞,杨明,姚英民.环磷腺苷葡胺和氨茶碱对小鼠急性缺氧性脑损伤的保护作用[J].中国优生与遗传杂志,2009,17(3):25-27.
[19] 陈涛,李栋,费舟,等.MCPG在神经元氧糖剥夺模型中的抗凋亡作用[J].中华神经外科疾病研究杂志,2010, 9(6):517-520.
[20] CilioMD,Donna MF,Synergistic neuroprotective therapies with hypothermia[J].Seminars in Fetal & Neonatal Medicine,2010,15:293-298.

基金

山东省自然科学基金青年基金项目(Q2008C13);国家人力资源与社会保障部留学人员科技活动择优资助项目(2009-416)

PDF(454 KB)

Accesses

Citation

Detail

段落导航
相关文章

/