骨龄测定在甲状腺功能减低症患儿诊断及治疗中的意义
- 闫晓莉,汪治华,李小青,潘秋红
作者信息
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Significance of bone age inspection in children with hypothyroidism
- YAN Xiao-li, WANG Zhi-hua, LI Xiao-qing, PAN Qiu-hong
Author information
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文章历史
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摘要
【目的】 观察甲状腺功能减低症患儿的骨龄发育情况,探讨骨龄测定在甲状腺功能减低症患儿诊断及治疗中的意义。 【方法】 对在本院内分泌门诊确诊为甲状腺功能减低症的37例患儿进行随访,于治疗前及治疗过程中拍摄左手及腕部正位X线片,应用《中国儿童骨龄评分法》进行骨龄评分,计算出骨龄。 【结果】 甲状腺功能减低症患儿的骨龄明显小于年龄,其差异有统计学意义(P<0.01);经替代治疗约2~3年后,骨龄与年龄相近。 【结论】 骨龄测定对甲状腺功能减低症患儿的诊断及疗效判断有重要的临床指导意义。
Abstract
【Objective】 To observe the bone age development in children with hypothyroidism and explore the potential applications in diagnosis and therapy of hypothyroidism. 【Method】 It was observed that 37 children's X-ray films of left hands and wrists and applied method for assessing bone age of Chinese children to score their bone age. 【Result】 The bone age of children with hypothyroidism were younger than their chronological age and the bone age caughted up the chronological age after treatment in the followed 2~3 years. 【Conclusion】 Bone age inspection has important instructional significance in diagnosis and treatment of hypothyroidism in children.
关键词
Key words
bone age / hypothyroidism / method for assessing bone age / thyroid hormone
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参考文献
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[2] 叶义言.中国儿童骨龄评分法[M] .北京: 人民卫生出版社,2005:11-55.
[3] 颜纯,王慕迪.小儿内分泌学[M].北京: 人民卫生出版社,2006:155-192.
[4] 程华,段晓岷,孙国强,等.儿童骨龄测定的临床应用价值[J].中国全科医学,2009,12(5):46-47.
[5] 迟素敏. 内分泌生理学[M].西安:第四军医大学出版社,2006:170-176.
[6] Bassett JH, Willams GR. The molecular actions of thyroid hormone in bone[J]. Trends Endocrinol Wetab,2003,14(8):356-364.
[7] Huang BK, Goloen LA, Tarjan G, et al. Insulin-like growth factor I production is essential for anabolic effects of thyroid hormone in osteoblasts [J]. Bone Miner Res, 2000, 15 (2):188-197.
[8] Adachi M, Asakura Y, Tachibana K. Final height and pubertal growth in Japanese patients with congenital hypothyroidism detected by neonatal screening[J]. Acta Paediatr, 2003,92(6):698-703.
基金
陕西省科技计划社会发展项目(2010K01-198)
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