【目的】 了解门诊注意缺陷多动障碍(attention deficient hyperactivity disorder, ADHD)患儿对哌甲酯治疗的依从性,及其可能的影响因素。 【方法】 对1999年1月—2007年1月间所有首次诊断为ADHD,并给予哌甲酯处方的患儿,根据自编的《ADHD儿童电话随访问卷》进行电话随访。 【结果】 共有病例325例,204例获得有效随访,84.31%(172例)的患儿接受哌甲酯治疗。用药达6个月以上患儿占用药人群的71.52%。依从性好者占总人群的28.4%。出现药物不良反应者占用药人群的29.7%,无严重不良反应事件发生。主要拒药或停药原因为:怕药物副作用。药物剂型和是否合并家长教育或小组治疗对依从性有影响作用。 【结论】 ADHD患儿家庭对药物治疗的依从性不高,长效制剂和父母小组干预有助于提高药物治疗依从性。

【Objective】 To study the compliance of attention deficient hyperactivity disorder(ADHD) patients on methylphenidate(MPH) and its possible influencing factors. 【Methods】 All patients diagnosed as ADHD in psychological counseling clinic of Children's Hospital of Fudan University during Jan 1999 to Jan 2007, and should be prescribed MPH at first time were enrolled. A self-designed questionnaire was administered by telephone. 【Results】 There were 325 ADHD patients in 8 years. 204 patients were successfully followed, 84.31% patients accepted MPH therapy, 71.52% in the MPH therapy group adhered to the medicine for more than 6 months. Only 28.4% of the whole studied population had good compliance. The main cause for families to refuse or stop MPH therapy was afraid of the side effects of medicine. The form of medicine and whether accompanied with parents education/group therapy had relation with MPH compliance. 【Conclusion】 The compliance of medicine therapy in ADHD families is low, and long-acting form and parents or group intervention will like to improve compliance.