【目的】 探讨品行障碍(conduct disorder, CD)青少年在静息态下脑功能磁共振的特点。 【方法】 对12名符合DSM-IV品行障碍诊断标准的12～18岁青少年和11名正常对照进行静息态的功能磁共振扫描,采用局部一致性(ReHo)作为测量指标进行数据分析,比较CD组和正常组间脑功能的差异。 【结果】 经过比较校正发现,与正常组相比,CD组在两侧额叶、左侧楔前叶和顶下小叶的ReHo值降低,在左侧颞叶、梭状回和右侧前扣带回ReHo值升高。 【结论】 与正常组相比,品行障碍青少年在静息状态下的脑功能存在异常,这些脑区可能在品行障碍的发病机制中起着重要的作用。
Abstract
【Objective】 To investigate the differences of brain spontaneous activity in resting state between adolescents with conduct disorder(CD) and matched controls using function magnetic imaging(fMRI). 【Method】 11 cases diagnosed with DSM-IV and 11 normal controls underwent resting-state fMRI, the data were analyzed using a newly reported method called Regional Homogeneity(ReHo) to analyze fMRI data between CD and normal controls. 【Result】 Compared with normal controls, CD showed decreased ReHo in bilateral frontal lobe and left inferior parietal and precuneus and increased in left temporal lobe and left fusiform gyrus and right anterior cingulated. 【Conclusion】 The results suggest that CD showed abnormal activity in resting state compared with the normal controls.
关键词
品行障碍 /
磁共振成像 /
局部一致性
Key words
conduct disorder /
magnetic resonance imaging /
regional homogeneity
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基金
国家“十一五”科技支撑计划的子课题(2007BAI17B03);上海市科学技术委员会科研计划项目(10411966300)
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