【目的】 通过青少年代谢综合征(metabolic syndrome, MS)相关组分的因子分析,探索青少年MS病理生理机制。 【方法】 以哈尔滨市某校130名高一学生为研究对象。测量身高、体重、腰围、臀围、收缩压、舒张压,计算体质指数、腰臀比和腰围身高比;测定空腹血糖、血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇及血清超敏C反应蛋白(high sensitivity C reactive protein, hs-CRP)含量。 【结果】 未引入hs-CRP变量时,提取三个公因子:肥胖因子、脂代谢因子和血压血糖因子,分别解释10个原始变量的31.730%、22.287%和16.767%,累计方差贡献率为70.784%。引入hs-CRP变量后,青少年MS相关组分共提取3个因子,分别为肥胖因子、脂代谢因子和血压血糖因子,分别解释10个原始变量的32.697%、20.275%、15.454%,累计方差贡献率为68.427%。 【结论】 肥胖因子在青少年MS发病机制中起主要作用;腰围身高比较腰围更适于评价青春期MS的中心性肥胖;hs-CRP可能参与青春期MS的发病。
Abstract
【Objective】 To identify the clustering characteristics of metabolic syndrome (MS) and to explore the mechanisms of it in adolescents by factor analysis. 【Methods】 130 students were sampled from a senior high school in Harbin. The height, weight, waist circumference, blood pressure (BP), the body mass index (BMI) and the waist-to-height ratio (WHtR) were measured or calculated. The FPG, TC, TG, HDL-C, and LDL were detected by automatic biochemical analyzer. The hs-CRP was detected. Spearman correlation and factor analysis were used by SPSS17.0 program. 【Results】 Without the hs-CRP, principal component factor analysis revealed three factors: adiposity, lipid-metabolic, blood pressure and carbohydrate-metabolic that cumulatively explained 70.784% of the observed variance of metabolic syndrome; With the hs-CRP, it revealed three factors: adiposity lipid-metabolic, blood pressure and carbohydrate-metabolic (DBP, SBP, FPG) that cumulatively explained 68.427% of the observed variance of metabolic syndrome. 【Conclusions】 Adiposity plays a major role in the pathogenesis of MS in adolescents; WHtR is more suitable for evaluating central obesity of MS in adolescents than WC; hs-CRP may be involved in the pathogenesis of MS in adolescents.
关键词
代谢综合征 /
因子分析 /
超敏C反应蛋白 /
青少年
Key words
metabolic syndrome /
factor analysis /
high sensitivity C reactive protein /
adolescents
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