锂对新生儿缺血缺氧性脑损伤神经保护作用的研究进展

王钰 综述, 尹晓娟 审校

中国儿童保健杂志 ›› 2011, Vol. 19 ›› Issue (11) : 1002-1004.

PDF(462 KB)
PDF(462 KB)
中国儿童保健杂志 ›› 2011, Vol. 19 ›› Issue (11) : 1002-1004.
综述与讲座

锂对新生儿缺血缺氧性脑损伤神经保护作用的研究进展

  • 王钰 综述, 尹晓娟 审校
作者信息 +
文章历史 +

摘要

在全世界的新生儿中,因窒息所造成的新生儿死亡率已达到23%[1],围生期窒息导致的缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)是造成新生儿死亡最常见原因.尽管有研究显示脑损伤后6h内采用亚低温治疗中度HIE可减少其致残率[2],重复注射小剂量的促红细胞生成素可降低其伤残率[3],但尚在研究阶段,迄今为止,上述治疗的有效性还尚未得出一致结论。锂在脑缺氧缺血后的神经保护作用已经引起人们的广泛关注,下面就锂的神经保护作用展开综述。

关键词

/ 神经保护 / 新生儿

引用本文

导出引用
王钰 综述, 尹晓娟 审校. 锂对新生儿缺血缺氧性脑损伤神经保护作用的研究进展[J]. 中国儿童保健杂志. 2011, 19(11): 1002-1004
中图分类号: R722   

参考文献

[1] Lawn JE,Cousens S,Zupan J.4 million neonatal deaths:when? Where? Why?[J].Lancet,2005,365(9462):891-900.
[2] Azzopardi DV,Strohm B,Edwards AD,et al.Moderate hypothermia to treat perinatal asphyxial encephalopathy[J].N Engl J Med,2009,361(14):1349-1358.
[3] Zhu C,Kang W, Xu F,et al.Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy[J].Pediatrics,2009,124(2e):218-226.
[4] Bian Q,Shi T,Chuang DM,et al.Lithium reduces ischemia-induced hippocampal CA1 damage and behavioral de?cits in gerbils[J].Brain Res,2007,1184(12):270-276.
[5] Xia Y,Wang CZ,Liu J,et al.Lithium protection of phencyclidine-induced neurotoxicity in developing brain: the role of phosphatidylinositol-3 kinase/Akt and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathways[J].J Pharmacol Exp Ther,2008,326(3):838-848.
[6] Crespo-Biel N,Camins A,Pallas M,et al.Evidence of calpain/cdk5 pathway inhibition by lithium in 3-nitropropionic acid toxicity in vivo and in vitro[J].Neuropharmacology,2009,56(2):422-428.
[7] Yan XB,Hou HL,Wu LM,et al.Lithium regulates hippocampal neurogenesis by ERK pathway and facilitates recovery of spatial learning and memory in rats after transient global cerebral ischemia[J].Neuropharmacology,2007,53(4):487-495.
[8] Kirshenboim N,Plotkin B,Shlomo SB,et al.Lithium-mediated phosphorylation of glycogen synthase kinase-3beta involves PI3 kinase-dependent activation of protein kinase C-alpha[J].J Mol Neurosci,2004,24(2):237-245.
[9] Zhang F,Phiel CJ,Spece L,et al.Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3[J].J Biol Chem,2003,278(35):33067-33077.
[10] Brywe KG,Mallard C,Gustavsson M,et al.IGF-Ineuroprotection in the immature brain after hypoxia-ischemia,involvement of Akt and GSK3beta[J] .Eur J Neurosci,2005,21(6):1489-1502.
[12] Li Q,Li H,Roughton K,et al.Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia[J].Cell Death Dis,2010,1(7):56-59.
[13] Zhu C,Wang X,Xu F,et al.The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia[J].Cell Death Differ,2005,12(2):162-176.
[14] Blomgren K,Zhu C,Wang X,et al.Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia:a mechanism of 'pathological apoptosis'?[J].Biol Chem,2001,276(13):10191-10198.
[15] Sarkar S,Floto RA.Lithium induces autophagy by inhibiting inositol monophosphatase[J].J Cell Biol,2005,170(7):1101-1111.
[16] Marmol F.Lithium:bipolar disorder and neurodegenerative diseases possible cellular mechanisms of the therapeutic effects of lithium[J].Prog Neuropsychopharmacol Biol Psychiatry,2008,32(8):1761-1771.
[17] Hu BR,Liu CL,Ouyang Y,et al.Involvement of caspase-3 in cell death after hypoxia-ischemia declines during brain maturation[J].J Cereb Blood Flow Metab,2000,20(9):1294-1300.
[18] Wang X,Carlsson Y,Basso E,et al.Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury[J].J Neurosci,2009,29(8):2588-2596.

PDF(462 KB)

Accesses

Citation

Detail

段落导航
相关文章

/