经颅直流电刺激在孤独症谱系障碍康复中的应用进展

张飞燕, 李鹤立, 李云杰, 赵瑾珠, 胡聪, 崔金茹, 赵煜, 郝燕

中国儿童保健杂志 ›› 2026, Vol. 34 ›› Issue (2) : 227-232.

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中国儿童保健杂志 ›› 2026, Vol. 34 ›› Issue (2) : 227-232. DOI: 10.11852/zgetbjzz2025-0111
综述

经颅直流电刺激在孤独症谱系障碍康复中的应用进展

  • 张飞燕, 李鹤立, 李云杰, 赵瑾珠, 胡聪, 崔金茹, 赵煜, 郝燕
作者信息 +

Advances in transcranial direct current stimulation for autism spectrum disorder rehabilitation

  • ZHANG Feiyan, LI Heli, LI Yunjie, ZHAO Jinzhu, HU Cong, CUI Jinru, ZHAO Yu, HAO Yan
Author information +
文章历史 +

摘要

孤独症谱系障碍(ASD)是一种以社交障碍、狭隘兴趣和重复刻板行为为特征的神经发育障碍性疾病,临床症状多变且治疗难度大。经颅直流电刺激(tDCS)作为一种非侵入性的脑刺激方式,通过调节局部皮层兴奋性改善ASD患者的临床症状,其机制涉及纠正异常的兴奋抑制比(E/I)、调节脑代谢物水平、优化大脑功能连通性及改善脑血流动力学等。本文综述tDCS在ASD治疗中的靶点选择、作用机制及临床疗效,并探讨其在ADHD、抑郁症等神经精神疾病中的扩展应用及安全性。

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits, restricted interests, and repetitive behaviors, exhibiting variable clinical manifestations and significant treatment challenges. As a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS) can alleviate clinical symptoms in individuals with ASD by modulating local cortical excitability. The underlying mechanisms involve correcting the abnormal excitation/inhibition (E/I) ratio, regulating levels of cerebral metabolites, optimizing functional brain connectivity, and improving cerebral hemodynamics. This article reviews the target selection, mechanisms of action, and clinical efficacy of tDCS in the treatment of ASD. It also explores its extended applications in other neuropsychiatric disorders such as ADHD and depression, as well as its safety profile.

关键词

孤独症谱系障碍 / 经颅直流电刺激 / 康复

Key words

autism spectrum disorder / transcranial direct current stimulation / rehabilitation

引用本文

导出引用
张飞燕, 李鹤立, 李云杰, 赵瑾珠, 胡聪, 崔金茹, 赵煜, 郝燕. 经颅直流电刺激在孤独症谱系障碍康复中的应用进展[J]. 中国儿童保健杂志. 2026, 34(2): 227-232 https://doi.org/10.11852/zgetbjzz2025-0111
ZHANG Feiyan, LI Heli, LI Yunjie, ZHAO Jinzhu, HU Cong, CUI Jinru, ZHAO Yu, HAO Yan. Advances in transcranial direct current stimulation for autism spectrum disorder rehabilitation[J]. Chinese Journal of Child Health Care. 2026, 34(2): 227-232 https://doi.org/10.11852/zgetbjzz2025-0111
中图分类号: R179   

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