目的 探究血清单胺氧化酶水平与儿童青少年肥胖程度及其与心血管代谢指标之间的关系,为肥胖及其相关并发症的预防和治疗提供理论依据。方法 于2018年4-11月对沈阳市1 007名中学生进行体检,包括身体测量和血清生化指标检测,并根据不同肥胖等级分组进行分析。结果 研究对象中肥胖率为14.40%,男性高于女性(16.33% vs. 12.48%)。单因素方差分析结果显示,肥胖组血清单胺氧化酶浓度比正常组高出16.32%[(8.48±2.10)U/L vs. (7.29±3.02)U/L,F＝9.874,P＜0.001];Logistic回归分析结果显示血清单胺氧化酶水平升高是发生肥胖的危险因素(OR=1.13,95%CI:1.06~1.20,P＜0.001);线性相关与回归分析发现血清单胺氧化酶水平与休重指数(β=0.083,95%CI:0.025-0.140,P=0.005)及门冬氨酸氨基转移酶(β=0.039,95%CI:0.003~0.075,P=0.032)水平相关。结论 血清单胺氧化酶水平升高是肥胖发生的危险因素,血清单胺氧化酶可能参与了脂代谢、糖代谢等与肥胖相关的生理过程。
Abstract
Objective To explore the relationship between serum monoamine oxidase level and obesity in children and adolescents and its correlation with cardiovascular and metabolic indexes,so as to provide theoretical basis for prevention and treatment of obesity and its related complications. Methods Totally 1 007 middle school students from Shenyang city were enrolled in this study to perform physical examination from April to Norember 2018,including body measurements and serum biochemical tests.And the results were analyzed according to different levels of obesity group. Results The rate of obesity was 14.40%,which was significantly higher in boys (16.33%) than girls (12.48%).One-way ANOVA showed that of the serum monoamine oxidase level of the obese group was higher than that of the normal by 16.32%[(8.48±2.10) U/L for obese group and (7.29±3.02) U/L for normal group,F=9.874,P＜0.001].Logistic regression analysis showed that the increase of serum monoamine oxidase was a risk factor for obesity(OR=1.13,95%CI:1.06-1.20,P＜0.001).Linear correlation and regression analysis showed that the serum monoamine oxidase level was correlated with body mass index(β=0.083,95%CI:0.025-0.140,P=0.005) and AST level (β=0.039,95%CI:0.003-0.075,P=0.032). Conclusion Serum monoamine oxidase might be involved in some physiological processes related to obesity such as fat metabolism and sugar metabolism,so that the increase of serum monoamine oxidase is a risk factor for obesity.
关键词
儿童青少年 /
肥胖 /
超重 /
单胺氧化酶
Key words
children and adolescents /
obesity /
overweight /
monoamine oxidase
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] NCD Risk Factor Collaboration.Worldwide trends in body-mass index,underweight,overweight,and obesity from 1975 to 2016:a pooled analysis of 2416 population-based measurement studies in 128.9 million children[J].Adolescents,and adults.Lancet (London,England),2017,390(10113):2627-2642.
[2] 贺媛,曾强,赵小兰.中国成人肥胖、中心性肥胖与高血压和糖尿病的相关性研究[J].解放军医学杂志,2015,40(10):803-808.
[3] 徐前.儿童肥胖与代谢综合征的相关性研究进展[J].中国妇幼保健,2016,31(10):2235-2237.
[4] Afshin A,Forouzanfar MH,Reitsma MB,et al.Health eff ects of overweight and obesity in 195 countries over 25 years[J].N Engl J Med,2017,377(1):13-27.
[5] Hare ML.Tyramine oxidase:A new enzyme system in liver[J].Biochem J,1928,22(4):968-979.
[6] Johnston JP.Some observations upon a new inhibitor of mo noamine oxidase in brain tissue[J].Biochem Pharmacol,1968,17(7):1285-1297.
[7] Bach AW,Lan NC,Johnson DL,et al.cDNA cloning of human liver monoamine oxidase A and B:molecular basis of differences in enzymatic properties[J].Proc Natl Acad Sci U S A,1988,85(13):4934-4938.
[8] 王练,付极,汪佑霞.血清单胺氧化酶活性测定对肝硬化的诊断意义[J].皖南医学院学报,1988,7(4):224-225.
[9] 祝莉. 肝硬化患者生化检验项目及血清ADA、MAO、AFU水平的变化与意义[J]. 现代医学与健康研究电子杂志,2020, 4(12):79-80.
[10] 王莉敏,方斌,方海啸,等.单胺氧化酶A/B亚型的活性检测在神经系统疾病诊疗中的应用[J]. 中国临床药理学与治疗学,2020,25(9):1052-1058.
[11] 中国肥胖问题工作组,季成叶.中国学龄儿童青少年超重、肥胖筛查体重指数值分类标准[J].中华流行病学杂志,2004,25(2):10-15.
[12] 李丽霞.正常儿童青春期性发育规律调查及分析[D].青岛:青岛大学,2005.
[13] Bortolato M,Chen K,Shih JC.Monoamine oxidase inactivation:from pathophysiology to therapeutics[J].Adv Drug Deliv Rev,2008,60(13-14):1527-1533.
[14] Youdim MB,Edmondson D,Tipton KF.The therapeutic potential of monoamine oxidase inhibitors[J].Nat Rev Neurosci,2006,7(4):295-309.
[15] 王石,董宪喆,谭潇,等.开心散对单胺氧化酶活性的影响[J].中国中药杂志,2016,41(10):1898-1902.
[16] 何庆华,吴永宁,印遇龙.食品中生物胺研究进展[J].中国食品卫生杂志,2007,19(5):451-454.
[17] Tong JH,D'Iorio A,Kandaswami C.On the characteristics of mitochondrial monoamine oxidase in pancreas and adipose tissues from genetically obese mice[J].Can J Biochem,1979,57(3):197-200.
[18] Wanecq E,Bour S,Verwaerde P,et al.Increased monoamine oxidase and semicarbazide-sensitive amine oxidase activities in white adipose tissue of obese dogs fed a high-fat diet[J].J Physiol Biochem,2006,62(2):113-123.
[19] Cater k,Nelson M,Robidoux J,et al.Kinetics of Neurotransmitter Metabolism by Monoamine Oxidase in Porcine Heart Differs by Location and is Increased with Obesity/Metabolic Syndrome[J].Faseb J,2017,31(Suppl):1.
[20] Nagy CT,Koncsos G,Varga ZV,et al.Selegiline reduces adiposity induced by high-fat,high-sucrose diet in male rats[J].Br J Pharmacol,2018,175(18):3713-3726.
[21] Cathcart MK,Bhattacharjee A.Monoamine oxidase A (M AO-A):a signature marker of alternatively activated monocytes/macrophages[J].Inflamm Cell Signal,2014,1(4)pii:e161.
[22] Emory H,Mizrahi N.Monoamine Oxidase Inhibition in a patient with type 1 diabetes and depression[J].J Diabetes Sci Technol,2016,10(5):1203-1204.
[23] Matsusue A,Kubo SI,Ikeda T,et al.VNTR polymorphism in the monoamine oxidase A promoter region and cerebrospinal fluid catecholamine concentrations in forensic autopsy cases[J].Neurosci Lett,2019,701:71-76.
[24] Kleinridders A,Cai W,Cappellucci L,et al.Insulin resistance in brain alters dopamine turnover and causes behavioral disorders[J].Proc Natl Acad Sci U S A,2015,112(11):3463-3468.
[25] Pizzinat N,Marti L,Remaury A,et al.High expression of monoamine oxidases in human white adipose tissue:evidence for their involvement in noradrenaline clearance[J].Biochem Pharmacol,1999,58(11):1735-1742.
[26] 吴张君,潘莹,乐圆. 血清AST、ALP、CHE、PT与乙型病毒性肝炎合并肺结核患者肝纤维化程度的相关性[J].中西医结合肝病杂志,2020,30(6): 509-511.
[27] 姚梦,白爽,李旭龙,等.综合干预对肥胖青少年糖脂代谢肝肾和心血管功能的影响[J].中国学校卫生,2019,40(4):582-585.
PDF(719 KB)
