目的 通过Meta分析了解我国儿童青少年生长迟缓流行情况,为生长迟缓儿童的早期防治提供科学依据。方法 检索中国期刊全文数据库(CNKI)、万方数据资源系统(Wanfang database)、中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)和PubMed数据库中截止到2020年3月30日的有关中国儿童生长迟缓患病率报道文献。根据STROBE声明中横断面研究评价标准进行文献质量评价,利用Stata 12.0软件合并患病率,并对性别、年龄、地区分布、调查年份、居住地等因素进行亚组分析,采用Egger检验及漏斗图评估各文献发表偏倚,通过排除其中任意一篇低质量文献对合并效应值的影响进行敏感性分析。结果 共纳入23篇文献,总样本量699 974人,变化范围为6 082~99 542(M=17 329)人。中国儿童青少年生长迟缓总患病率为6.0%(95%CI:5.0%~7.0%)。亚组分析显示0~7岁患病率8.1%(95%CI:6.0%~10.2%),7~18岁患病率3.3%(95%CI:2.7%~3.9%),差异有统计学意义(t＝4.12,P<0.05)。在2005-2010年调查的患病率9.9%(95%CI:7.5%~12.2%),在2011-2019年调查患病率3.0%(95%CI:2.2%~3.7%),差异有统计学意义(t＝6.49,P<0.05)。农村患病率4.5%(95%CI:3.4%~5.7%),城市患病率2.5%(95%CI:1.9%~3.1%),差异有统计学意义(t＝2.94,P<0.05)。不同性别、地区分布之间差异无统计学意义(P>0.05)。结论 我国儿童生长迟缓患病率呈现下降趋势,不同年龄组、居住地患病率存在差别,应引起重视。
Abstract
Objective To understand the prevalence of growth retardation among children and adolescents in China through Meta analysis, in order to provide scientific basis for early prevention and treatment of growth retardation in children. Methods Literatures about the prevalence of growth retardation among children in China were retrieved from CNKI, Wanfang data, CBM, VIP and PubMed databases up to March 30th, 2020.Literature quality was evaluated according to the cross-sectional study evaluation criteria in STROBE statement.The prevalence rate was combined with Stata 12.0 software.Subgroup analysis was carried out on factors such as gender, age, regional distribution, year of investigation and residence.Egger test and funnel plot were used to evaluate the publication bias of each literature.The sensitivity analysis was completed by eliminating any one of low-quality articles. Results A total of 23 articles were included, with a total sample size of 699 974, ranging from 6 082 to 99 542(M=17 329).The overall prevalence of growth retardation in Chinese children was 6.0% (95%CI:5.0%-7.0%).Subgroup analysis showed that the prevalence rates of growth retardation in children aged 0-7 years and 7-18 years were 8.1%(95%CI:6.0%-10.2%) and 3.3%(95%CI:2.7%-3.9%), and the difference was significant(t＝4.12,P<0.05).The prevalence rate of growth retardation was 9.9%(95%CI:7.5%-12.2%) in 2005—2010, and 3.0%(95%CI:2.2%-3.7%) in 2011-2019, the difference was significant (t＝6.49,P<0.05).The prevalence rate of growth retardation was 4.5% (95%CI:3.4%-5.7%) in rural area and 2.5%(95%CI:1.9%-3.1%) in urban area,the defference was significant(t＝2.94,P<0.05).But the difference was not significant between different genders and regional distribution. Conclusion The prevalence rate of children's growth retardation is decreasing in China, and there are differences among different age groups and residence.
关键词
生长迟缓 /
儿童 /
Meta分析
Key words
stunting /
children /
Meta-analysis
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基金
无锡市“科教强卫工程”医学青年人才项目(QNRC091);无锡市卫生健康委妇幼健康科研项目(FYKY201901);无锡市太湖人才计划高层次人才培养项目(HB2020071)
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