维生素D缺乏与儿童感染性疾病

杨茜, 李元霞, 贾鲲鹏, 马科

中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (6) : 653-656.

PDF(610 KB)
PDF(610 KB)
中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (6) : 653-656. DOI: 10.11852/zgetbjzz2019-1004
综述

维生素D缺乏与儿童感染性疾病

  • 杨茜, 李元霞, 贾鲲鹏, 马科
作者信息 +

Vitamin D deficiency and infectious diseases in children

  • YANG Xi, LI Yuan-xia, JIA Kun-peng, MA Ke
Author information +
文章历史 +

摘要

维生素D是维持人体健康必不可少的营养素,不仅参与钙磷代谢,维持骨健康,而且作为一种免疫调节剂,在感染性疾病中发挥着重要作用。维生素D主要通过促进抗菌肽的产生、影响免疫调节等功能发挥辅助抗感染作用。本文将对维生素D缺乏和其与感染性疾病的相关性做一简要综述。

Abstract

Vitamin D is an irreplaceable nutrient for human health.It not only participates in calcium and phosphorus metabolism,maintaining bone health,but also plays an important role in infectious diseases as an immune regulator.Vitamin D also plays an auxiliary role in anti-infection by promoting the production of antimicrobial peptides and affecting immune regulation.This paper reviews Vitamin D deficiency and its association with infectious diseases.

关键词

维生素D缺乏 / 感染性疾病 / 儿童

Key words

vitamin D deficiency / infectious diseases / children

引用本文

导出引用
杨茜, 李元霞, 贾鲲鹏, 马科. 维生素D缺乏与儿童感染性疾病[J]. 中国儿童保健杂志. 2020, 28(6): 653-656 https://doi.org/10.11852/zgetbjzz2019-1004
YANG Xi, LI Yuan-xia, JIA Kun-peng, MA Ke. Vitamin D deficiency and infectious diseases in children[J]. Chinese Journal of Child Health Care. 2020, 28(6): 653-656 https://doi.org/10.11852/zgetbjzz2019-1004
中图分类号: R725.1   

参考文献

[1] 仰曙芬,吴光驰.维生素D缺乏及维生素D缺乏性佝偻病防治建议解读[J].中国儿童保健杂志,2015,23(7):680-683.
[2] Schleicher RL,Sternberg MR,Looker AC,et a1.National estimates of serum total 25-hydroxyvitamin D and metabolite concentrations measured by liquid chromatography-tandem mass spectrometry in the US population during 2007-2010[J].J Nutr,20l6,146(5):1051-1061.
[3] Hu YC,Chen J,Wang R,et al.Vitamin D nutritional status and its related factors for chinese children and adolescents in 2010-2012.[J].Nutrients,2017,9(9):1024.
[4] 沈燕,张增利,宋媛,等.苏州地区0~6岁儿童维生素D营养状况调查分析[J].国际检验医学杂志,2019,40(2):199-202.
[5] 朱庆龄,陈俊伟,林卫华,等.泉州地区0一12岁儿童25羟维生素D水平分析[J].中华实用儿科临床杂志,2018,33(11):842-845.
[6] 郑双双,詹建英,朱冰泉,等.中国儿童维生素D营养状况流行病学研究进展[J].中华儿科杂志,2019,57(3):232-234.
[7] Wang TJ,Zhang F,Richards JB,et al.Common genetic determinants of vitamin D insufficiency:a genome wide association study[J].Lancet,2010,376(9736):180-188.
[8] Petta S,Grimaudo S,Marco VD,et al.Association of vitamin D serum levels and its common genetic determinants,with severity of liver fibrosis in genotype 1 chronic hepatitis C patients[J].J Viral Hepat,2013,20(7):486-493.
[9] Farrar MD,Webb AR,Kift R,et a1.Efficacy of a dose range of simulated sunlight exposures in raising vitamin D status in South Asian adults:implications for targeted guidance on sun exposure[J].Am J Clin Nutr,2013,97(6):1210-1216.
[10] 徐磊,杨玉.单纯性肥胖儿童血清25羟维生素D水平检测及临床意义[J].中国妇幼保健,2016,31(13):2660-2663.
[11] Kensarah OA,Jazar AS,Azzeh FS.Hypovitaminosis D in healthy toddlers and preschool children from western Saudi Arabia[J].Int J Vitam Nutr Res,2015,85(12):50-60.
[12] Jari M,Qorbani M,Moafi M,et al.Association of 25-hydroxy Vitamin D level with indexes of general and abdominal obesity in Iranian adolescents:The CASPIAN-Ⅲ study[J].J Res Med Sci,2015,20(2):122-126.
[13] Wagner CL,Greer FR.Prevention of rickets and vitamin D deficiency in infants,children,and adolescents.[J].Pediatrics,2008,122(5):1142-1152.
[14] Holick MF,Binkley NC,Bischoff-Ferrari HA,et al,Evaluation,treatment,and prevention of vitamin D deficiency:An endocrine society clinical practice guideline[J].J Clin Endocrinol Metab,2011,96(7):1911-1930.
[15] Society for Adolescent Health and Medicine.Recommended vitamin D intake and management of low vitamin D status in adolescents:a position statement of the society for adolescent health and medicine[J].J Adolesc Health,2013,52(6):801-803.
[16] 中华医学会儿科学分会儿童保健学组,《中华儿科杂志》编辑委员会.儿童微量营养素缺乏防治建议[J].中华儿科杂志,2010,48(7):502-509.
[17] 全国佝偻病防治科研协作组,中国优生科学协会小儿营养专业委员会.维生素D缺乏及维生素D缺乏性佝偻病防治建议[J].中国儿童保健杂志,2015,23(7):781-782.
[18] Munns CF,Shaw N,Kiely M,et a1.Global consensus recommendations on prevention and management of nutritional rickets[J].J Clin Endocrinol Metab,2016,101(2):394-415.
[19] 阎雪,韩笑,张会丰.2016版“营养性佝偻病防治全球共识”解读[J].中华儿科杂志,2016,54(12):891-895.
[20] Larkin A,Lassetter J.Vitamin D deficiency and acute lower respiratory infections in children younger than 5 Years:identification and treatment[J].J Pediatr Health Care,2014,28(6):572-582.
[21] 邓永超,唐喜春,袁远宏,等.婴幼儿重症肺炎维生素D水平动态变化及相关性分析[J].中国当代儿科杂志,2018,20(11):911-916.
[22] 王博玉,柏金秀,贾浩,等.儿童反复上呼吸道感染与血浆抗菌肽LL-37及维生素D水平的相关性研究[J].中国儿童保健杂志,2019,27(8):913-916.
[23] 方彩文,邹旭凤,徐小娟,等.学龄前儿童反复呼吸道感染危险因素及与维生素D相关性分析[J].中国儿童保健杂志,2019,27(06):673-676.
[24] Parekh D,Patel JM,Scott A,et al,Vitamin D deficiency in human and murine sepsis[J].Crit Care Med,2017,45(2):282-289.
[25] 黄伟,夏明月,李明丽,等.急性腹泻患儿血清25-羟维生素D与炎性细胞因子水平的关系[J].山东医药,2017,57(10):58-59.
[26] 冯鹏华.补充维生素D对轮状病毒感染性腹泻的疗效和对 Th1 细胞因子的影响[J].职业与健康,2016,32(3):364-367.
[27] 胡晓艳,周于新,徐颂周.维生素D与新生儿宫内感染的关系[J].中国妇幼保健,2017,32(7):1517-1518.
[28] Hewison M.Vitamin D and the intracrinology of innate immunity[J].Mol Cell Endocrinol,2010,321(2):103-111.
[29] Abhimanyu,Coussens AK.The role of UA radiation and vitamin D in the seasonality and outcomes of infectious disease[J].Photochem Photobiol Sci,2017,16(3):314-338.
[30] Van Etten E,Mathieu C.Immunoregulation by 1,25-dihyd roxyvitamin D3:basic concepts.[J].J Steroid Biochem Mol Biol,2005,97(1):93-101.
[31] Liu PT,Stenger S,Li H,et al.Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response[J].Science,2006,311(5768):1770-1773.
[32] 张爱飞,冯正平.维生素D免疫调节的研究进展[J].中国骨质疏松杂志,2019,25(4):564-569.
[33] Xhindoli D,Pacor C,Benincasa M,et al.The human cathelicidin LL-37-A pore-forming antibacterial peptide and host-cell modulator[J].Biochim Biophys Acta,2016,1858(3):546-566.
[34] 张晓丹,赵贝,李光慧,等.维生素D缺乏与感染发生的相关性及其机制研究进展[J].中国药房,2018,29(5):710-715.
[35] Subramanian K,Bergman P,Henriques-nor-mark B.Vitam in D promotes pneumococcal killing and modulates in flammatory responses in primary human neutrophils[J].J Innate Immun,2017,9(4):375-386.
[36] Chen Y,Liu W,Sun T,et al.1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages[J].J Immunol,2013,190(7):3687-3695.
[37] Kundu R,Theodoraki A,Haas CT,et al.Cell-type-specific modulation of innate immune signalling by vitamin D in human mononuclear phagocytes[J].J Immunol,2017,150(1):55-63.
[38] Ferreira GB,Kleijwegt FS,Waelkens E,et al.Differential pr otein pathways in 1,25-dihydroxyvitamin D3 and dexamethasone modulated tolerogenic human dendritic cells[J].J Proteome Res,2012,11(12):941-971.
[39] Vanherwegen AS,Gysemans C,Mathieu C.Vitamin D endocrinology on the cross-road between immunity and metabolism[J].Mol Cell Endocrinol,2017,453(9):52-67.
[40] 邢娜,任立红.儿童血清维生素D、自噬、免疫调节及机体各系统疾病的相关性综述[J].中国儿童保健杂志,2020,28(3):288-291.

基金

中华国际科学交流基金会(Z2018LSXB009)

PDF(610 KB)

Accesses

Citation

Detail

段落导航
相关文章

/