目的 分析1～18月龄正常婴幼儿脑干听觉诱发电位(BAEP)的变化规律,为建立婴幼儿BAEP波 Ⅰ、Ⅲ、Ⅴ潜伏期及Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ波间期的参考值范围提供科学依据。方法 选取2017年1月—2018年1月于湖北省妇幼保健院就诊的609例听力正常婴幼儿(共1 218耳)为研究对象和40例听力正常成人(共80耳)为对照组,进行BAEP测试。结果 1～18月龄婴儿Ⅰ、Ⅲ、Ⅴ波潜伏期及Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ波间期随月龄增长而缩短。Ⅰ波潜伏期至6月龄后与成人相近(P＞0.05)。Ⅲ、Ⅴ波潜伏期及Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ波间期至7月龄仍未达到成人水平(P＜0.05),Ⅴ波,Ⅰ-Ⅴ波间期在9月仍未达到成人水平(P＜0.05)。各波潜伏期及波间期性别及左右耳比较,差异无统计学意义(P＞0.05)。结论 建立1～18月龄婴幼儿BAEP潜伏期及波间期参考值标准,为听力及发育障碍的早期诊断和随访检测提供参考依据。
Abstract
Objective To investigate the characteristics of brainstem auditory evoked potential(BAEP) in healthy infants aged 1 to 18 months,so as to establish normal range of the peak latencies(PLs) of wave Ⅰ,Ⅲ,Ⅴ and interpeak latencies(IPLs) of Ⅰ-Ⅲ,Ⅲ-Ⅴ,Ⅰ-Ⅴ.Methods Totally 609 healthy children with normal hearing(1 218 ears) in Hubei Maternal and Children′s Hospital were enrolled in this study from January 2017 to January 2018,and 40 healthy adults(80 ears) were selected as control group.BAEP test was conducted in the participants. Results The PLs of wave Ⅰ,Ⅲ,Ⅴ and IPLs of Ⅰ-Ⅲ,Ⅲ-Ⅴ,Ⅰ-Ⅴ of normal infants aged 1 to 18 months became shorter with the increase of age.The PL of waⅤe I was not near that of adults until 6 months old. The PLs of Ⅲ,Ⅴ waⅤe and IPLs of Ⅰ-Ⅲ,Ⅲ-Ⅴ and Ⅰ-Ⅴ failed to reach adults levels even for 7-month-old infants(P＜0.05). And Ⅴ wave and Ⅰ-Ⅴ failed to reach adults levels even for 9-month-old infants(P＜0.05). No significant differences on the PLs of waves were found between different age groups or different side of ears(P＞0.05). Conclusion The establishment of normal range of PLs and IPLs for BAEP waves in infants aged 1 to 18 months can provide a reliable basis for early diagnosis and follow-up detection of hearing and development disorders.
关键词
听性脑干诱发电位 /
正常参考值 /
婴幼儿
Key words
brainstem auditory evoked potential /
normal reference value /
infant
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参考文献
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基金
中国疾病预防控制中心妇幼保健中心儿童早期发展适宜技术研究项目(2017FYE004)
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