目的 了解儿童血清维生素A(VA)的营养现状,为儿童科学补充VA提供更多依据。方法 采用横断面研究,选择于2017年9月—2018 年8月在哈尔滨市儿童医院儿童保健门诊进行常规体检的3 163名0~16岁健康儿童为研究对象。收集儿童的年龄及性别等基本信息,采用高效液相色谱法检测儿童的血清VA水平。结果 3 163名0~16岁儿童血清VA平均水平为(0.30±0.08)mg/L;0~、0.5~、1~、3~、6~、12~16岁的儿童血清VA水平分别为(0.20±0.04)、(0.23±0.04)、(0.33±0.06)、(0.30±0.05)、(0.35±0.06)mg/L以及(0.44±0.08)mg/L;6月龄以上儿童整体血清VA异常率为52.2%(1 572/3 012),其中VA缺乏率和不足率分别为5.7%(172/3 012)和46.5%(1 400/3 012);0.5~组血清VA异常率最高,高达98.8 %,不同年龄组儿童血清VA异常率差异均有统计学意义(χ2=998.70,P＜0.001)。结论 儿童的VA营养不良仍然是一项严峻的公共卫生问题,应更多的关注VA不足/缺乏率较高的儿童群体。
Abstract
Objective To investigate vitamin A level of children,in order to provide theoretical basis for scientific supplement of vitamin A. Methods A cross-sectional study was conducted. Totally 3 163 individuals aged 0 to 16 years who took physical examination in Child Care Clinic of Harbin Children′s Hospital from September,2017 to August,2018 were enrolled in this study. Information of participants such as gender and age were recorded. Serum level of vitamin A was determined by high performance liquid chromatography. Results The average level of serum vitamin A was(0.30±0.08) mg/L for all participants,and were(0.20±0.04),(0.23±0.04),(0.33±0.06),(0.30±0.05),(0.35±0.06)mg/L and(0.44±0.08) mg/L for 0—,0.5—,1—,3—,6— and 6—12 years old groups,respectively. The overall incidences of vitamin A abnormal in children aged over 6 months were 52.2%(1 572/3 012),in which the incidence of vitamin A deficiency and insufficiency were 5.7 %(172/3 012) and 46.5%(1 400/3 012),respectively. The prevalence of abnormal level of vitamin A was 98.8 % in children more than 6 months old. There was significant difference on the rate of abnormal level of vitamin A among children in different age groups(χ2=998.70,P＜0.001). Conclusion Vitamin A malnutrition is still a serious public health problem and more attention is supposed to be paid to children with high rate of vitamin A deficiency and insufficiency.
关键词
维生素A水平 /
儿童 /
横断面研究
Key words
vitaminAlevel /
children /
cross-sectionalstudy
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基金
黑龙江省卫生计生委科研课题(2017-234)
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