新生儿感染是引起新生儿发病及死亡的重要原因,尤其是极低出生体重早产儿。新生儿由于免疫系统发育不成熟,较容易受到病原体的入侵,引发不同的感染性疾病。在我国新生儿感染中,感染性肺炎最为常见,其次是败血症和肠道感染,严重损害新生儿的健康。由于多肽较强的广谱性抗菌作用以及进化上的保守性使其成为广泛研究的热点。已有多项研究证实多肽在新生儿抗感染中的作用,并且能够抑制耐药性细菌,有望为新生儿抗感染治疗提供新方法。本文将对多肽在新生儿感染引发的肺炎、败血症、坏死性小肠结肠炎中的研究进展做进一步阐述。
Abstract
Neonatal infection,especially among very-low-birth-weight preterm infants,is a significant cause of neonatalmorbidity and mortality.Their immune system is immaturity rendering them vulnerable to the invasion of pathogens,causing different infectious diseases.In China,infectious pneumonia is the most common in neonatal infectious disease,followed by sepsis and intestinal infection.Due to potent broad-spectrum antimicrobial activity and evolutionarily conservedin a variety of organisms of peptides,they have attracted extensive attentions of researchers.Several studies have confirmed the anti-infection effect and functional against microbes with antibiotic resistance of peptides in neonate.Based on these properties,they are expected to become future therapeutics for neonatal infection.This review addresses the developments of the main peptides in neonatal infectious disease including infectious pneumonia,sepsis and necrotizing enterocolitis.
关键词
新生儿感染 /
多肽 /
肺炎 /
败血症 /
坏死性小肠结肠炎
Key words
neonatal infection /
polypeptide;pneumonia /
sepsis /
necrotizing enterocolitis
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参考文献
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基金
国家973计划项目(2013CB530604);国家自然科学基金(81330067;81401232;81501296;81601333);南京市医学科技发展杰出青年基金项目(JQX13012)
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