多肽是一种介于氨基酸和蛋白质之间、具有其独特生物学活性的化合物,依据其来源不同分为内源性多肽和外源性多肽。内源性多肽含量丰富、产生形式多样,受到研究者的关注。近期发现非编码基因同样可以编码具有生物活性的小分子肽,从lncRNA、rRNA、microRNA等寻找新的具有编码功能的开放阅读框成为新近研究的热点。内源性多肽作用方式多样,不仅可以分泌后通过与受体结合发挥类似激素的作用,也可以产生后在胞内发挥功能。随着多肽作为药物越来越多地应用于临床,内源性多肽无疑具有广泛的应用前景。本文介绍内源多肽的产生和作用方式,重点综述新的研究发现和研究进展,旨在为内源性多肽的研究提供参考。
Abstract
Peptide is a specifical bioactive substances between amino acids and proteins,which are divided into endogenous peptides and exogenous peptides.Endogenous peptides gain more and more attentions due to the content enrich and various production ways.Recent study revealed that nocoding genes also could code bioactive peptide,and now to find new potential coding open reading frames from lncRNA,rRNA and microRNA is becoming a hot research area.Endogenous peptides could play in many ways,such as binding to its receptor after secretion or working intracellular.As the more application of peptide in the clinic as drugs,there is no doubt that endogenous peptides will have broad application foreground.Here,we make a brief description on the birth and function of peptide,and focus on its new discovery and research progress to provide reference for endogenous peptides research.
关键词
多肽 /
胞内肽 /
体液内源性肽 /
作用方式
Key words
peptide /
intracellular peptide /
body fluids endogenous peptides /
mode of action
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参考文献
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基金
国家973计划项目(2013CB530604);国家自然科学基金(81670773)
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