目的 通过分析孤独症谱系障碍(ASD)儿童综合干预开始的年龄及持续时间对治疗效果的影响,以期为ASD儿童综合干预开始年龄及持续时间、改善ASD儿童生活质量提供理论参考依据。方法 对符合《美国精神障碍诊断与统计手册》(第4版)(DSM-Ⅳ) ASD诊断标准的221名儿童进行以应用行为分析-语言行为教学为主的综合干预治疗,采用自身前后对照研究。使用孤独症谱系障碍儿童行为检查量表(ABC)进行综合干预治疗效果分析。结果 综合干预后ABC量表感觉、交往、运动、语言、自理因子分及总分均较综合干预前下降(P<0.000 1),且开始综合干预年龄越小、综合干预的持续时间越长,ABC量表各因子分及总分的变化越大(P<0.000 1)。结论 开始综合干预年龄越小、综合干预持续时间越长,ASD儿童感觉、交往、运动、语言、自理能力改善越好。

Objective To analyse the efficacy of different age to begin comprehensive intervention and duration of comprehensive intervention of children with autism spectrum disorders (ASD),and to provide a reference for improving the quality of life of children with ASD. Methods A total of 221 children were diagnosed as ASD according to American Psychiatric Diagnostic Statistical Manual 4^th edition criteria (DSM-Ⅳ) and conducted the self controlled study of comprehensive intervention treatment.Autism Behavior Checklist (ABC) was used to analyse the efficacy. Results There were significant differences in scores of feeling,sports,language,and social/self-control factors of ABC between before and after therapy,between different age to start comprehensive intervention and comprehensive intervention duration(P<0.000 1).Started earlier and the longer duration of comprehensive intervention,the differences of the each factor and total scores of ABC rating scale were statistically significant. Conclusions Comprehensive intervention can improve the ASD abilities of feeling,sports,language,and social/self-control.At the same time,the more effective is by younger to start comprehensive intervention and longer duration of comprehensive intervention.