目的 探讨试管双胎婴儿与自然妊娠双胎婴儿临床特征的差异性,为完善试管双胎婴儿的临床管理提供指导。方法 选取172对试管双胎婴儿和476对自然妊娠双胎婴儿为研究对象,收集其性别、母亲年龄、出生身长、出生体重、早产、胎龄、出生后合并症、NICU住院、出生缺陷、死亡等信息,比较两组婴儿间的差异。结果 试管婴儿母亲生育时年龄、双胎体重差、体重差异率以及新生儿低血糖/高血糖、感染、心脏相关疾病、呼吸系统疾病发生比例均高于自然妊娠婴儿;试管婴儿胎龄小于自然妊娠婴儿,以上差异均有统计学意义(P＜0.05)。结论 应加强试管双胎婴儿分娩的监测,注意新生儿血糖异常、感染、心脏相关疾病、呼吸系统疾病的发生,早期积极处理避免不良结局的发生。
Abstract
Objective To explore the differences of clinical characteristics between in vitro fertilization-embryo transfer (IVF-ET) twins and natural pregnancy twins,and provide guidance for clinical management of IVF-ET twins. Methods Totally 172 pairs of twins after IVF-ET and 476 pairs of natural pregnancy twins were selected as the research objects,the data about their gender,maternal age,birth length,birth weight,premature,gestational age,neonatal complications,NICU admission rate,neonatal mortality and morbidity were collected,and the differences between the two groups were compared. Results The average maternal age,the twin birth weight discordance,the birth weight discordance rate,neonatal hypoglycemia/hyperglycemia,neonatal infection,neonatal heart related disease,respiratory disease of IVF-ET twins were higher than those of the natural pregnancy group(P＜0.05).The gestational age of the IVF-ET group was less than the natural pregnancy group(P＜0.05). Conclusion Postoperative IVF-ET newborn monitoring should be strengthened.We should pay attention to the occurrence of neonatal blood glucose abnormalities,neonatal infection,neonatal heart related diseases and respiratory disease,and try to focus on aforementioned symptoms at early stage actively so as to prevent undesirable outcomes.
关键词
体外受精-胚胎移植 /
双胎妊娠 /
新生儿
Key words
in vitro fertilization-embryo transfer /
twin pregnancy /
newborn
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