肥胖儿童的数量增长迅速,预计到2020年,肥胖儿童发病率将增长至9.1%,大约有将近6 000万超重和肥胖儿童。肥胖能引起各种严重危害健康的并发症,并且肥胖能使许多疾病及死亡提前到来。其中代谢综合征即为肥胖引起的并发症之一,代谢综合征是指一组以代谢性异常为共同特征的疾病包括糖耐量异常,高血压,血脂代谢紊乱及中心性肥胖。尽管许多医疗机构及组织认同肥胖,高血压,脂质代谢紊乱和血糖代谢异常应该被纳入代谢综合征的诊断,但是关于代谢综合征,目前仍没有十分统一的标准。我国对青少年及儿童代谢综合征的诊断主要采用2012年中华医学会儿科学分会内分泌遗传代谢学组制定的标准,根据我国儿童生长发育特点,新的标准主要包括以下四个方面:1)肥胖;2)高血糖;3)高血压;4)脂代谢紊乱。目前,对于代谢综合征,临床治疗目标就是通过综合治疗干预手段提高个体及全人类的健康,减少代谢综合征引起的不良后果。其中,最基础的治疗手段是通过生活及运动干预方式减轻体重,其次是治疗代谢综合征引起的并发症。
关键词
儿童肥胖 /
代谢综合征 /
诊断标准 /
治疗方案
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] De Onis M,Blssner M,Borghi E.Global prevalence and trends of overweight and obesity among preschool children[J].The American Journal of Clinical Nutrition,2010,92(5):1257-1264.
[2] Apoutsakis C,Dedoussis GV.Gene-diet interactions in childhood obesity:Paucity of evidence as the epidemic of childhood obesity continues to rise[J].Personalized Medicine,2007,4(2):133-146.
[3] Hu G,Qiao Q,Tuomilehto J,et al.Plasma insulin and cardiovascular mortality in non-diabetic European men and women:a meta-analysis of data from eleven prospectivestudies[J].Diabetologia,2004,47:1245-1256.
[4] Chen SJ,Yen CH,Huang YC,et al.Relationships between inflammation,adiponectin,and oxidative stress in metabolic syndrome[J].PLoS One,2012,7:e45693.
[5] Devaraj S,Valleggi S,Siegel D,et al.Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome[J].Curr Atheroscler Rep,2010,12:110-118.
[6] Lambert GW,Straznicky NE,Lambert EA,et al.Sympathetic nervous activation in obesity and the metabolic syndrome-causes,consequences and therapeutic implications[J].Pharmacol Ther,2010,126:159-172.
[7] Alberti KG,Eckel RH,Grundy SM,et al.Harmonizing the metabolic syndrome:a joint interim statement of the international diabetes federation task force on epidemiology and prevention;national heart,lung,and blood institute;American heart association;world heart federation;international atherosclerosis society;and international association for the study of obesity[J].Circulation,2009,120:1640-1645.
[8] Mozumdar A,Liguori G.Persistent increase of prevalence of metabolic syndrome among U.S.adults:NHANES III toNHANES 1999-2006[J].Diabetes Care,2011,34:216-219.
[9] 中华医学会儿科学分会内分泌遗传代谢学组,中华医学会儿科学分会心血管学组,中华医学会儿科学分会儿童保健学组.中国儿童青少年代谢综合征定义和防治建议[J].中华儿科杂志,2012,50(6):420-422.
[10] 陈雪峰,梁黎,傅君芬,等.中国儿童青少年形体测量学指数调查[J].中华流行病学杂志,2012,33(5):449-454.
[11] 米杰,王天有,孟玲慧,等.中国儿童青少年血压参照标准的研究制定[J].中国循证儿科杂志,2010,5(1):4-14.
[12] Kraschnewski JL,Boan J,Esposito J,et al.Long-term weight loss maintenance in the United States[J].Int J Obes,2010,34:1644-1654.
[13] National Association for Sport and Physical Education.Moving into the future:national standards for physical education[M/OL].2nd edition.Available at:http:// www.aahperd.org/naspe/standards/national Stan-dards/standardsbackground.cfm?renderforprint=1.2012.
[14] National Association for Sport and Physical Education.Physical activity for children:a statement of guidelines for children ages 5~12[M/OL].2nd edition.Available at:http:// www.aahperd.org/naspe/standards/nationalGuidelines/PA-Children-5-12.cfm?renderforprint=1.2012.
[15] Steiner MJ,Skinner AC,Perrin EM.Fasting might not be necessary before lipid screening:a nationally representative cross-sectional study[J].Pediatrics,2011,128:463-470.
[16] Luttikhuis HO,Baur L,Jansen H,et al.Interventions for treating obesity in children[J].Cochrane Database Syst Rev 2009,1:CD001872.
[17] U.S.Department of Agriculture,U.S.Department of Health and Human Services.Dietary guidelines for Americans 2005[M].6th Edition.U.S.Government printing office,Washington,DC,2005.
[18] USDA Evidence Analysis Library.Is intake of dietary fiber related to adiposity in children?[S].2012.
[19] US. Department of Health and Human Services.In Dietary Guidelines for Americans,2010[M].7th Edition,Washington,DC:U.S.Government Printing Office,December 2010.
[20] Raub RM,Goldberg SJ.Assessment of metformin as an additional treatment to therapeutic lifestyle changes in pediatric patients with metabolic syndrome[M].Cholesterol,2012:961410.
[21] National Heart,Lung,and Blood Institute.Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents:summary report[M].NIH Publication,2012,12-7486A.