新生儿缺氧缺血性脑损伤神经功能障碍及神经再生新认识

柴妍楠 综述, 尹晓娟 审校

中国儿童保健杂志 ›› 2015, Vol. 23 ›› Issue (1) : 46-48.

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中国儿童保健杂志 ›› 2015, Vol. 23 ›› Issue (1) : 46-48. DOI: 10.11852/zgetbjzz2015-23-01-14
综述与讲座

新生儿缺氧缺血性脑损伤神经功能障碍及神经再生新认识

  • 柴妍楠 综述, 尹晓娟 审校
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摘要

新生儿缺氧缺血性脑损伤(hypoxic-ischemic brain damage,HIBD)是由围生期缺氧所引起的严重疾病,可以导致神经元功能长期丧失,甚至死亡。存活者中一部分患儿会遗留脑瘫、癫痫、精神障碍、认知,感觉及运动障碍等一系列后遗症。然而,目前尚无有效的治疗方式可以保护脑组织在缺氧缺血过程中免受损伤。主要是不能确定缺氧缺血发生的准确时间,且不能准确地识别每一个病人损伤和修复的确切时相点。越来越多的研究用来探讨缺氧缺血性脑损伤及其神经功能障碍的结构机理,以期进一步在新生儿期对该病进行神经靶点保护机制的研究。本文主要从缺氧缺血性脑损伤的神经系统改变和干细胞为基础的再生治疗策略入手,就内源性神经疗法、外源性神经疗法、神经干细胞的临床试验、尚未解决的问题等进行综述。

关键词

缺氧缺血 / 新生儿 / 脑损伤 / 神经组织发生 / 再生

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导出引用
柴妍楠 综述, 尹晓娟 审校. 新生儿缺氧缺血性脑损伤神经功能障碍及神经再生新认识[J]. 中国儿童保健杂志. 2015, 23(1): 46-48 https://doi.org/10.11852/zgetbjzz2015-23-01-14
中图分类号: R722.1   

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